QUCEED PLUS 

INSTRUCTIONS FOR USE

KUSID PLUS

QUCEED PLUS  

 

Trade name of the drug : Kyusid Plus

Active ingredients (INN ): aluminum hydroxide, magnesium hydroxide, simethicone

Dosage form : suspension for oral administration.

Compound

Kyusid Plus with pineapple flavor

every 5 ml of suspension contains:

active substances :

aluminum hydroxide dry 400 mg;

magnesium hydroxide 400 mg;

simethicone 40 mg;

excipients : polysorbate 60, sorbitan monostearate, sodium methylhydroxybenzoate, sodium propylhydroxybenzoate, guar (Luctoman), propylene glycol, liquid sorbitol (not crystalline), hydrogen peroxide solution 50%, sucralose, butylated hydroxytaluene, quinoline yellow color, pineapple essence (Singapore) ;

Kyusid Plus with strawberry flavor

every 5 ml of suspension contains:

active substances :

aluminum hydroxide dry 400 mg;

magnesium hydroxide 400 mg;

simethicone 40 mg;

excipients : polysorbate 60, sorbitan monostearate, sodium methylhydroxybenzoate, sodium propylhydroxybenzoate, guar (Luctoman), propylene glycol, liquid sorbitol (not crystalline), hydrogen peroxide solution 50%, sucralose, butylated hydroxytaluene, color: Ponceau 4R, strawberry essence;

Kyusid Plus with mango flavor

every 5 ml of suspension contains:

active substances :

aluminum hydroxide dry 400 mg;

magnesium hydroxide 400 mg;

simethicone 40 mg;

excipients : polysorbate 60, sorbitan monostearate, sodium methylhydroxybenzoate, sodium propylhydroxybenzoate, guar (Luctoman), propylene glycol, liquid sorbitol (not crystalline), hydrogen peroxide solution 50%, sucralose, butylated hydroxytaluene, sunset yellow, mango essence;

Kyusid Plus with banana flavor

every 5 ml of suspension contains:

active substances :

aluminum hydroxide dry 400 mg;

magnesium hydroxide 400 mg;

simethicone 40 mg;

excipients : polysorbate 60, sorbitan monostearate, sodium methylhydroxybenzoate, sodium propylhydroxybenzoate, guar (Luctoman), propylene glycol, liquid sorbitol (not crystalline), hydrogen peroxide solution 50%, sucralose, butylated hydroxytaluene, banana essence.

Description :

Pineapple flavored:  greenish-yellow homogeneous suspension with pineapple flavor, sweet in taste.

Strawberry flavored:  pink homogeneous suspension with strawberry flavor, sweet in taste.

Mango flavored:  light yellow homogeneous suspension with mango flavor, sweet in taste.

Banana flavored:  white or almost white homogeneous suspension with banana flavor, sweet in taste.

Pharmacotherapeutic group : antiulcer agent (antacid).

ATX code : A02AF02

 

Pharmacological properties

Kyusid Plus is a balanced combination of two antacids: aluminum hydroxide and magnesium hydroxide. Magnesium hydroxide has a rapid, and aluminum hydroxide a prolonged antacid effect. Peptic activity is inhibited by both antacids due to an increase in gastric pH. Aluminum hydroxide has direct antipeptic activity, as well as a property that helps protect the lining of the gastrointestinal tract and prevents further irritation or erosion, which promotes healing. Aluminum hydroxide has a weak fixing effect, and magnesium hydroxide has a mild laxative property; the balance of these effects prevents the occurrence of constipation or diarrhea. Both antacids are not absorbed into the systemic circulation and practically do not cause the risk of developing alkalosis.

Simethicone is an auxiliary agent in this drug and prevents gas formation in the digestive tract. This property is a consequence of a change in the surface tension of gas bubbles, as a result of which they merge. This allows trapped gases to escape and be eliminated from the body through regurgitation or passage through the rectum. The dispersal of gas bubbles facilitates the contact of antacids and improves the envelopment of the mucous membrane by the antacid and emollient components of the drug. Simethicone has been well studied and is widely used. It has a quick effect and is non-toxic. Being physiologically neutral, it does not affect digestion and is not absorbed through the gastrointestinal mucosa.

 

Pharmacokinetics

Kyusid Plus is a non-absorbable drug. If the correct dosage regimen and duration of treatment are observed, it is practically not resorbed in the gastrointestinal tract and has a long-lasting, uniform effect without disturbing the electrolyte balance and without creating the risk of alkalosis or other metabolic disorders. It does not irritate the urinary system and, with long-term use, does not cause alkalosis and the formation of stones in the urinary tract.

 

Indications for use

• acute gastritis with increased acidity;
• peptic ulcer of the stomach and duodenum (exacerbation);
• esophagitis;
• food poisoning;
• duodenitis, enteritis;
• hiatal hernia in the diaphragm;
• flatulence;
• diarrhea;
• pain or discomfort in the abdomen after dietary violations, excessive intake of alcohol, coffee, nicotine, or taking various medications;
• prophylactic use of Kyusid Plus is advisable to prevent the development of ulcerative lesions when using non-steroidal anti-inflammatory drugs and glucocorticosteroids.

 

Directions for use and doses

Adults and children over 6 years of age are prescribed 1-2 sachets orally 2-3 times a day.

For gastroesophageal reflux and diaphragmatic hernia ,  the drug is taken immediately after meals and at night;

For gastric and duodenal ulcers  – 1-2 hours after eating and immediately if pain occurs;

For gastritis , dyspepsia  – before meals;

For functional diseases of the colon  – in the morning on an empty stomach and at night.

If pain returns between doses of Kyusid Plus, taking the drug can be repeated.

The drug can be taken pure or diluted in half a glass of water before use.

 

Side effects

In rare cases (<1/10000), allergic reactions (urticaria, bronchospasm, anaphylactic reactions) are possible. Taking large amounts (more than recommended doses) of calcium carbonate can cause alkalosis, hypercalcemia, milk-alkali syndrome, rebound phenomenon, and constipation.

 

Contraindications

• severe renal dysfunction;
• Alzheimer’s disease;
• individual hypersensitivity to the components of the drug;
• age up to 6 years.

 

Drug interactions

Benzocaine should not be used in combination with sulfonamides (antagonist of the antibacterial effect).

When taking Kyusid Plus together with tetracyclines, cardiac glycosides, ketoconazole, histamine H1 receptor blockers _, iron-containing drugs, ciprofloxacin, isoniazid, phenothiazine, rinitidine and cimetidine, insoluble compounds are formed, which reduces the absorption of the drugs.

 

special instructions

The interval between taking Cusid Plus and other medications should be 1-2 hours.

When taking the drug for a long time, you should ensure a sufficient intake of phosphorus from food.

The drug should be used with caution in case of kidney disease, liver cirrhosis, or severe heart failure.

If constipation occurs while taking Kyusid Plus, it is recommended to increase the amount of water consumed daily.

The drug should be stored out of the reach of children and not used after the expiration date.

 

Overdose

Symptoms : shallow breathing, dry mouth, constipation or diarrhea, headache, weakness, fatigue, aching bones, stupor.

Treatment : symptomatic.

 

Release form

Suspension for oral administration.

5 ml in a bag made of aluminum foil and PVC. 60 sachets in a cardboard box. 6 cardboard packs in one cardboard box for transportation.

10 ml in a bag made of aluminum foil and PVC. 60 sachets in a cardboard box. 6 cardboard packs in one cardboard box for transportation.

30 ml in a bag made of aluminum foil and PVC. 20 sachets in a cardboard box. 6 cardboard packs in one cardboard box for transportation.

 

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25°C.

 

Best before date

3 years.

 

Conditions for dispensing from pharmacies

Over the counter.

 

Made in India   

“Avison Pharmaceuticals Pvt. Ltd.”, India

“Coral Laboratories Limited.”,

Plot No. 27-28, Pharmacity, Selaqui,

Dehradun, Uttarakhand-248197, India